Ontology highlight
ABSTRACT:
SUBMITTER: Carlsson AE
PROVIDER: S-EPMC3146262 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
The mechanisms by which cytoskeletal flows and cell-substrate interactions interact to generate cell motion are explored using a simplified model of the cytoskeleton as a viscous gel containing active stresses. This model yields explicit general results relating cell speed and traction forces to the distributions of active stress and cell-substrate friction. It is found that 1) the cell velocity is given by a function that quantifies the asymmetry of the active-stress distribution, 2) gradients ...[more]