Unknown

Dataset Information

0

Mechanisms of Cell Propulsion by Active Stresses.


ABSTRACT: The mechanisms by which cytoskeletal flows and cell-substrate interactions interact to generate cell motion are explored using a simplified model of the cytoskeleton as a viscous gel containing active stresses. This model yields explicit general results relating cell speed and traction forces to the distributions of active stress and cell-substrate friction. It is found that 1) the cell velocity is given by a function that quantifies the asymmetry of the active-stress distribution, 2) gradients in cell-substrate friction can induce motion even when the active stresses are symmetrically distributed, 3) the traction-force dipole is enhanced by protrusive stresses near the cell edges or contractile stresses near the center of the cell, and 4) the cell velocity depends biphasically on the cell-substrate adhesion strength if active stress is enhanced by adhesion. Specific experimental tests of the calculated dependences are proposed.

SUBMITTER: Carlsson AE 

PROVIDER: S-EPMC3146262 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Mechanisms of Cell Propulsion by Active Stresses.

Carlsson A E AE  

New journal of physics 20110701


The mechanisms by which cytoskeletal flows and cell-substrate interactions interact to generate cell motion are explored using a simplified model of the cytoskeleton as a viscous gel containing active stresses. This model yields explicit general results relating cell speed and traction forces to the distributions of active stress and cell-substrate friction. It is found that 1) the cell velocity is given by a function that quantifies the asymmetry of the active-stress distribution, 2) gradients  ...[more]

Similar Datasets

| S-EPMC6825260 | biostudies-literature
| S-EPMC7251099 | biostudies-literature
| S-EPMC8279480 | biostudies-literature
| S-EPMC4387529 | biostudies-literature
| S-EPMC3107263 | biostudies-other
| S-EPMC3169002 | biostudies-literature
| S-EPMC3765296 | biostudies-other
| S-EPMC7536071 | biostudies-literature
| S-EPMC7706714 | biostudies-literature
| S-EPMC7468500 | biostudies-literature