Ontology highlight
ABSTRACT:
SUBMITTER: Meghana C
PROVIDER: S-EPMC3107263 | biostudies-other | 2011 May
REPOSITORIES: biostudies-other
Meghana C C Ramdas Nisha N Hameed Feroz Meeran FM Rao Madan M Shivashankar G V GV Narasimha Maithreyi M
Proceedings of the National Academy of Sciences of the United States of America 20110513 22
Tissue patterning relies on cellular reorganization through the interplay between signaling pathways and mechanical stresses. Their integration and spatiotemporal coordination remain poorly understood. Here we investigate the mechanisms driving the dynamics of cell delamination, diversely deployed to extrude dead cells or specify distinct cell fates. We show that a local mechanical stimulus (subcellular laser perturbation) releases cellular prestress and triggers cell delamination in the amniose ...[more]