Ontology highlight
ABSTRACT:
SUBMITTER: Gizinski AM
PROVIDER: S-EPMC3146352 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Gizinski Alison M AM Fox David A DA Sarkar Sujata S
Best practice & research. Clinical rheumatology 20100801 4
Full activation and differentiation of resting T cells into effector T cells requires at least two signals, the first through engagement of the T cell antigen receptor (TCR) by the antigen-major histocompatibility complex (MHC) on antigen-presenting cells (APCs), and the second by engagement of co-stimulatory molecules such as CD28, on T cells by ligands such as CD80/86 on APCs. Effector T cell differentiation is associated with proliferation, secretion of cytokines and expression of additional ...[more]