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HIV PATHOGENESIS-EMERGING CONCEPTS.


ABSTRACT: CD4 receptor molecules on 'T' lymphocytes and macrophages have already been identified as the route of entry for HIV. However CCR5 and CXCR4 are identified only recently as the second receptors for HIV on macrophages and 'T' lymphocytes respectively. Presence of homozygous CCR5 Δ 32, a defective CCR5 gene leads to resistance to HIV infection in the risk groups. While heterozygous CCRS Δ 32 leads to delay in the progress of HIV infection to AIDS.

SUBMITTER: Misra RN 

PROVIDER: S-EPMC5531965 | biostudies-other | 2000 Jan

REPOSITORIES: biostudies-other

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