Ontology highlight
ABSTRACT:
SUBMITTER: Vengellur A
PROVIDER: S-EPMC3147003 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Vengellur Ajith A Grier Elizabeth E Lapres John J JJ
Journal of toxicology 20110717
Wild-type and HIF1α -/- MEF cells were used to determine the role of HIF1α in cadmium-induced toxicity. Cadmium treatment did not affect HIF1-mediated transcription but led to caspase activation and apoptotic cell death in wild-type and HIF1α -/- cells. Cadmium-induced cell death, however, was significantly higher in HIF1α -/- cells as compared to their wild-type counterparts. Increased cell death in the HIF1α -/- cells was correlated with lower metallothionein protein, elevated levels of reacti ...[more]