Ontology highlight
ABSTRACT:
SUBMITTER: de Iriarte Rodriguez R
PROVIDER: S-EPMC4575698 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
de Iriarte Rodríguez Rocío R Magariños Marta M Pfeiffer Verena V Rapp Ulf R UR Varela-Nieto Isabel I
Cellular and molecular life sciences : CMLS 20150515 20
The family of RAF kinases transduces extracellular information to the nucleus, and their activation is crucial for cellular regulation on many levels, ranging from embryonic development to carcinogenesis. B-RAF and C-RAF modulate neurogenesis and neuritogenesis during chicken inner ear development. C-RAF deficiency in humans is associated with deafness in the rare genetic insulin-like growth factor 1 (IGF-1), Noonan and Leopard syndromes. In this study, we show that RAF kinases are expressed in ...[more]