Ontology highlight
ABSTRACT:
SUBMITTER: Lei H
PROVIDER: S-EPMC3147322 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Lei Han H Sheng Zhina Z Ding Qian Q Chen Jian J Wei Xiaohui X Lam Dominic Man-Kit DM Xu Yuhong Y
Clinical and vaccine immunology : CVI 20110601 7
The development of safe and efficient avian influenza vaccines for human and animal uses is essential for preventing virulent outbreaks and pandemics worldwide. In this study, we constructed a recombinant (pgsA-HA1 gene fusion) Lactococcus lactis strain that expresses and displays the avian influenza virus HA1 antigens on its surface. The vectors were administered by oral delivery with or without the addition of cholera toxin subunit B (CTB). The resulting immune responses were analyzed, and the ...[more]