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Genetic characterization of multidrug-resistant, extended-spectrum- ?-lactamase-producing Vibrio cholerae O1 outbreak strains, Mpumalanga, South Africa, 2008.

ABSTRACT: Thirty-one antimicrobial-resistant, extended-spectrum-?-lactamase-producing strains of Vibrio cholerae O1 serotype Ogawa associated with an outbreak of cholera in South Africa (2008) were investigated. Ten selected cholera strains were PCR positive for the SXT element, harbored mutations in the quinolone resistance-determining regions of GyrA (Ser83-Ile) and ParC (Ser85-Leu), and produced TEM-63 ?-lactamase.

SUBMITTER: Ismail H

PROVIDER: S-EPMC3147719 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Genetic characterization of multidrug-resistant, extended-spectrum- β-lactamase-producing Vibrio cholerae O1 outbreak strains, Mpumalanga, South Africa, 2008.

Ismail Husna H Smith Anthony M AM Sooka Arvinda A Keddy Karen H KH

Journal of clinical microbiology 20110608 8

Thirty-one antimicrobial-resistant, extended-spectrum-β-lactamase-producing strains of Vibrio cholerae O1 serotype Ogawa associated with an outbreak of cholera in South Africa (2008) were investigated. Ten selected cholera strains were PCR positive for the SXT element, harbored mutations in the quinolone resistance-determining regions of GyrA (Ser83-Ile) and ParC (Ser85-Leu), and produced TEM-63 β-lactamase. ...[more]

PMID: 21653763

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