Ontology highlight
ABSTRACT:
SUBMITTER: Fokine A
PROVIDER: S-EPMC3147960 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Fokine Andrei A Islam Mohammad Z MZ Zhang Zhihong Z Bowman Valorie D VD Rao Venigalla B VB Rossmann Michael G MG
Journal of virology 20110601 16
The head of bacteriophage T4 is decorated with 155 copies of the highly antigenic outer capsid protein (Hoc). One Hoc molecule binds near the center of each hexameric capsomer. Hoc is dispensable for capsid assembly and has been used to display pathogenic antigens on the surface of T4. Here we report the crystal structure of a protein containing the first three of four domains of Hoc from bacteriophage RB49, a close relative of T4. The structure shows an approximately linear arrangement of the p ...[more]