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Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling.


ABSTRACT: Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk.

SUBMITTER: Morrison CS 

PROVIDER: S-EPMC3148067 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling.

Morrison Charles S CS   Chen Pai-Lien PL   Kwok Cynthia C   Richardson Barbra A BA   Chipato Tsungai T   Mugerwa Roy R   Byamugisha Josaphat J   Padian Nancy N   Celentano David D DD   Salata Robert A RA  

AIDS (London, England) 20100701 11


Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who u  ...[more]

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