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Does bacterial vaginosis modify the effect of hormonal contraception on HIV seroconversion.


ABSTRACT: OBJECTIVES:A recent study of HIV serodiscordant couples found that depot medroxyprogesterone acetate (DMPA) and oral contraceptive pills (OCPs) were associated with increased HIV risk in the presence, but not in the absence, of bacterial vaginosis. We assessed whether bacterial vaginosis is an effect modifier of the association between hormonal contraception and HIV seroconversion in female sex workers (FSWs) in Mombasa, Kenya. DESIGN:Prospective cohort study. METHODS:Data collected from HIV-negative FSWs from 1993 to 2017 were analyzed. Cox proportional hazards models were used to assess the relationship between HIV seroconversion and use of DMPA, OCPs, or hormonal contraceptive implants (Norplant, Jadelle). RESULTS:A total of 1985 women contributed 7127 person-years of follow-up; 307 women seroconverted to HIV (4.32/100 person-years). DMPA was significantly associated with elevated risk of HIV seroconversion in women with [aHR 1.56, 95% confidence interval (CI) 1.08-2.25; P?=?0.02] and without (aHR 2.08, 95% CI 1.46-2.97; P?

SUBMITTER: Sabo MC 

PROVIDER: S-EPMC6501800 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Does bacterial vaginosis modify the effect of hormonal contraception on HIV seroconversion.

Sabo Michelle C MC   Richardson Barbra A BA   Lavreys Ludo L   Martin Harold L HL   Jaoko Walter W   Mandaliya Kishorchandra K   Baeten Jared M JM   Overbaugh Julie J   McClelland R Scott RS  

AIDS (London, England) 20190601 7


<h4>Objectives</h4>A recent study of HIV serodiscordant couples found that depot medroxyprogesterone acetate (DMPA) and oral contraceptive pills (OCPs) were associated with increased HIV risk in the presence, but not in the absence, of bacterial vaginosis. We assessed whether bacterial vaginosis is an effect modifier of the association between hormonal contraception and HIV seroconversion in female sex workers (FSWs) in Mombasa, Kenya.<h4>Design</h4>Prospective cohort study.<h4>Methods</h4>Data  ...[more]

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