Ontology highlight
ABSTRACT:
SUBMITTER: Sasaki S
PROVIDER: S-EPMC3148747 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Sasaki Sanae S Sullivan Meghan M Narvaez Carlos F CF Holmes Tyson H TH Furman David D Zheng Nai-Ying NY Nishtala Madhuri M Wrammert Jens J Smith Kenneth K James Judith A JA Dekker Cornelia L CL Davis Mark M MM Wilson Patrick C PC Greenberg Harry B HB He Xiao-Song XS
The Journal of clinical investigation 20110725 8
During seasonal influenza epidemics, disease burden is shouldered predominantly by the very young and the elderly. Elderly individuals are particularly affected, in part because vaccine efficacy wanes with age. This has been linked to a reduced ability to induce a robust serum antibody response. Here, we show that this is due to reduced quantities of vaccine-specific antibodies, rather than a lack of antibody avidity or affinity. We measured levels of vaccine-specific plasmablasts by ELISPOT 1 w ...[more]