Ontology highlight
ABSTRACT:
SUBMITTER: Glanville SH
PROVIDER: S-EPMC3149129 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Glanville Stephanie H SH Bekiaris Vasileios V Jenkinson Eric J EJ Lane Peter J L PJ Anderson Graham G Withers David R DR
European journal of immunology 20090101 1
In this report we describe a transplantation system where embryonic spleens are grafted into adult hosts. This model can be used to analyze the cellular and molecular requirements for the development and organization of splenic microenvironments. Whole embryonic day 15 (ED15) spleens, grafted under the kidney capsule of adult mice, were colonized by host-derived lymphocytes and DC and developed normal splenic architecture. Grafts were also able to form germinal centers in response to T-dependent ...[more]