Ontology highlight
ABSTRACT:
SUBMITTER: Asmuth DM
PROVIDER: S-EPMC6279130 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Asmuth David M DM Thompson Corbin G CG Chun Tae-Wook TW Ma Zhong-Min ZM Mann Surinder S Sainz Talia T Serrano-Villar Sergio S Utay Netanya S NS Garcia Juan Carlos JC Troia-Cancio Paolo P Pollard Richard B RB Miller Christopher J CJ Landay Alan A Kashuba Angela D AD
The Journal of infectious diseases 20171001 7
Plasma, duodenal, and rectal tissue antiretroviral therapy (ART) drug concentrations, human immunodeficiency virus (HIV) RNA and HIV DNA copy numbers, and recovery of mucosal immunity were measured before and 9 months after initiation of 3 different ART regimens in 26 subjects. Plasma and tissue HIV RNA correlated at baseline and when 9-month declines were compared, suggesting that these compartments are tightly associated. Antiretroviral tissue:blood penetration ratios were above the 50% inhibi ...[more]