Ontology highlight
ABSTRACT:
SUBMITTER: Charkoudian LK
PROVIDER: S-EPMC3149197 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Charkoudian Louise K LK Liu Corey W CW Capone Stefania S Kapur Shiven S Cane David E DE Togni Antonio A Seebach Dieter D Khosla Chaitan C
Protein science : a publication of the Protein Society 20110701 7
The assembly-line architecture of polyketide synthases (PKSs) provides an opportunity to rationally reprogram polyketide biosynthetic pathways to produce novel antibiotics. A fundamental challenge toward this goal is to identify the factors that control the unidirectional channeling of reactive biosynthetic intermediates through these enzymatic assembly lines. Within the catalytic cycle of every PKS module, the acyl carrier protein (ACP) first collaborates with the ketosynthase (KS) domain of th ...[more]