Ontology highlight
ABSTRACT:
SUBMITTER: Barajas JF
PROVIDER: S-EPMC5161458 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20161001 42
In fungal non-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (ACP) carries the growing polyketide intermediate through iterative rounds of elongation, cyclization and product release. This process occurs through a controlled, yet enigmatic coordination of the ACP with its partner enzymes. The transient nature of ACP interactions with these catalytic domains imposes a major obstacle for investigation of the influence of protein-protein interactions on polyketide product outcome. ...[more]