TMKink: a method to predict transmembrane helix kinks.
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ABSTRACT:
SUBMITTER: Meruelo AD
PROVIDER: S-EPMC3149198 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
TMKink: a method to predict transmembrane helix kinks.
Meruelo Alejandro D AD Samish Ilan I Bowie James U JU
Protein science : a publication of the Protein Society 20110602 7
A hallmark of membrane protein structure is the large number of distorted transmembrane helices. Because of the prevalence of bends, it is important to not only understand how they are generated but also to learn how to predict their occurrence. Here, we find that there are local sequence preferences in kinked helices, most notably a higher abundance of proline, which can be exploited to identify bends from local sequence information. A neural network predictor identifies over two-thirds of all ...[more]
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