Ontology highlight
ABSTRACT:
SUBMITTER: Lee SF
PROVIDER: S-EPMC3149338 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Lee Sheu-Fen SF Srinivasan Bhooma B Sephton Chantelle F CF Dries Daniel R DR Wang Bing B Yu Cong C Wang Yun Y Dewey Colleen M CM Shah Sanjiv S Jiang Jin J Yu Gang G
The Journal of biological chemistry 20110617 31
Notch is a transmembrane receptor that controls a diverse array of cellular processes including cell proliferation, differentiation, survival, and migration. The cellular outcome of Notch signaling is dependent on extracellular and intracellular signals, but the complexities of its regulation are not well understood. Canonical Notch signaling involves ligand association that triggers sequential and regulated proteolysis of Notch at several sites. Ligand-dependent proteolysis at the S2 site remov ...[more]