Ontology highlight
ABSTRACT:
SUBMITTER: Seegar TCM
PROVIDER: S-EPMC5773094 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Seegar Tom C M TCM Killingsworth Lauren B LB Saha Nayanendu N Meyer Peter A PA Patra Dhabaleswar D Zimmerman Brandon B Janes Peter W PW Rubinstein Eric E Nikolov Dimitar B DB Skiniotis Georgios G Kruse Andrew C AC Blacklow Stephen C SC
Cell 20171207 7
Cleavage of membrane-anchored proteins by ADAM (a disintegrin and metalloproteinase) endopeptidases plays a key role in a wide variety of biological signal transduction and protein turnover processes. Among ADAM family members, ADAM10 stands out as particularly important because it is both responsible for regulated proteolysis of Notch receptors and catalyzes the non-amyloidogenic α-secretase cleavage of the Alzheimer's precursor protein (APP). We present here the X-ray crystal structure of the ...[more]