COPI acts in both vesicular and tubular transport.
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ABSTRACT:
SUBMITTER: Yang JS
PROVIDER: S-EPMC3149785 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
COPI acts in both vesicular and tubular transport.
Yang Jia-Shu JS Valente Carmen C Polishchuk Roman S RS Turacchio Gabriele G Layre Emilie E Layre Emilie E Moody D Branch DB Leslie Christina C CC Gelb Michael H MH Brown William J WJ Corda Daniela D Luini Alberto A Hsu Victor W VW
Nature cell biology 20110703 8
Intracellular transport occurs through two general types of carrier, either vesicles or tubules. Coat proteins act as the core machinery that initiates vesicle formation, but the counterpart that initiates tubule formation has been unclear. Here, we find that the coat protein I (COPI) complex initially drives the formation of Golgi buds. Subsequently, a set of opposing lipid enzymatic activities determines whether these buds become vesicles or tubules. Lysophosphatidic acid acyltransferase-γ (LP ...[more]
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