Ontology highlight
ABSTRACT:
SUBMITTER: Park SY
PROVIDER: S-EPMC4449304 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Park Seung-Yeol SY Yang Jia-Shu JS Schmider Angela B AB Soberman Roy J RJ Hsu Victor W VW
Nature 20150506 7553
The Golgi complex has a central role in the intracellular sorting of secretory proteins. Anterograde transport through the Golgi has been explained by the movement of Golgi cisternae, known as cisternal maturation. Because this explanation is now appreciated to be incomplete, interest has developed in understanding tubules that connect the Golgi cisternae. Here we show that the coat protein I (COPI) complex sorts anterograde cargoes into these tubules in human cells. Moreover, the small GTPase C ...[more]