Ontology highlight
ABSTRACT:
SUBMITTER: Divangahi M
PROVIDER: S-EPMC3150169 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Divangahi Maziar M Desjardins Danielle D Nunes-Alves Cláudio C Remold Heinz G HG Behar Samuel M SM
Nature immunology 20100711 8
The fate of infected macrophages has an essential role in protection against Mycobacterium tuberculosis by regulating innate and adaptive immunity. M. tuberculosis exploits cell necrosis to exit from macrophages and spread. In contrast, apoptosis, which is characterized by an intact plasma membrane, is an innate mechanism that results in lower bacterial viability. Virulent M. tuberculosis inhibits apoptosis and promotes necrotic cell death by inhibiting production of prostaglandin E(2). Here we ...[more]