Ontology highlight
ABSTRACT:
SUBMITTER: Hinchey J
PROVIDER: S-EPMC1934588 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Hinchey Joseph J Lee Sunhee S Jeon Bo Y BY Basaraba Randall J RJ Venkataswamy Manjunatha M MM Chen Bing B Chan John J Braunstein Miriam M Orme Ian M IM Derrick Steven C SC Morris Sheldon L SL Jacobs William R WR Porcelli Steven A SA
The Journal of clinical investigation 20070801 8
The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the secA2 gene in Mycobacterium tuberculosis, which encodes a component of a virulence-associated protein secretion system, enhanced the apoptosis of infected macrophages by diminishing secretion of mycobacterial superoxide dismutase. Deletion of secA2 markedly increased priming of antigen-specific CD8(+) T cells in vivo, and vaccination of mi ...[more]