Adult neural function requires MeCP2.
Ontology highlight
ABSTRACT:
SUBMITTER: McGraw CM
PROVIDER: S-EPMC3150190 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Adult neural function requires MeCP2.
McGraw Christopher M CM Samaco Rodney C RC Zoghbi Huda Y HY
Science (New York, N.Y.) 20110602 6039
Rett syndrome (RTT) is a postnatal neurological disorder caused by mutations in MECP2, encoding the epigenetic regulator methyl-CpG-binding protein 2 (MeCP2). The onset of RTT symptoms during early life together with findings suggesting neurodevelopmental abnormalities in RTT and mouse models of RTT raised the question of whether maintaining MeCP2 function exclusively during early life might protect against disease. We show by using an inducible model of RTT that deletion of Mecp2 in adult mice ...[more]
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