Ontology highlight
ABSTRACT:
SUBMITTER: Bertulat B
PROVIDER: S-EPMC3480415 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Bertulat Bianca B De Bonis Maria Luigia ML Della Ragione Floriana F Lehmkuhl Anne A Milden Manuela M Storm Christian C Jost K Laurence KL Scala Simona S Hendrich Brian B D'Esposito Maurizio M Cardoso M Cristina MC
PloS one 20121024 10
The X-linked Mecp2 is a known interpreter of epigenetic information and mutated in Rett syndrome, a complex neurological disease. MeCP2 recruits HDAC complexes to chromatin thereby modulating gene expression and, importantly regulates higher order heterochromatin structure. To address the effects of MeCP2 deficiency on heterochromatin organization during neural differentiation, we developed a versatile model for stem cell in vitro differentiation. Therefore, we modified murine Mecp2 deficient (M ...[more]