Ontology highlight
ABSTRACT:
SUBMITTER: Herold KC
PROVIDER: S-EPMC3150302 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Herold Kevan C KC Pescovitz Mark D MD McGee Paula P Krause-Steinrauf Heidi H Spain Lisa M LM Bourcier Kasia K Asare Adam A Liu Zhugong Z Lachin John M JM Dosch H Michael HM
Journal of immunology (Baltimore, Md. : 1950) 20110720 4
Type 1 diabetes mellitus is believed to be due to the autoimmune destruction of β-cells by T lymphocytes, but a single course of rituximab, a monoclonal anti-CD20 B lymphocyte Ab, can attenuate C-peptide loss over the first year of disease. The effects of B cell depletion on disease-associated T cell responses have not been studied. We compare changes in lymphocyte subsets, T cell proliferative responses to disease-associated target Ags, and C-peptide levels of participants who did (responders) ...[more]