Ontology highlight
ABSTRACT:
SUBMITTER: Palanichamy A
PROVIDER: S-EPMC4082756 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Palanichamy Arumugam A Jahn Sarah S Nickles Dorothee D Derstine Mia M Abounasr Aya A Hauser Stephen L SL Baranzini Sergio E SE Leppert David D von Büdingen H-Christian HC
Journal of immunology (Baltimore, Md. : 1950) 20140613 2
In multiple sclerosis (MS), B cell-depleting therapy using monoclonal anti-CD20 Abs, including rituximab (RTX) and ocrelizumab, effectively reduces disease activity. Based on indirect evidence, it is generally believed that elimination of the Ag-presenting capabilities and Ag nonspecific immune functions of B cells underlie the therapeutic efficacy. However, a small subset of T lymphocytes (T cells) was shown to also express CD20, but controversy prevails surrounding the true existence of this T ...[more]