Ontology highlight
ABSTRACT:
SUBMITTER: Batchelor JD
PROVIDER: S-EPMC3150435 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Batchelor Joseph D JD Zahm Jacob A JA Tolia Niraj H NH
Nature structural & molecular biology 20110710 8
Plasmodium vivax and Plasmodium knowlesi invasion depends on the parasite Duffy-binding protein DBL domain (RII-PvDBP or RII-PkDBP) engaging the Duffy antigen receptor for chemokines (DARC) on red blood cells. Inhibition of this key interaction provides an excellent opportunity for parasite control. There are competing models for whether Plasmodium ligands engage receptors as monomers or dimers, a question whose resolution has profound implications for parasite biology and control. We report cry ...[more]