Ontology highlight
ABSTRACT:
SUBMITTER: Brabin C
PROVIDER: S-EPMC3150447 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Brabin Charles C Appleford Peter J PJ Woollard Alison A
PLoS genetics 20110804 8
Seam cells in Caenorhabditis elegans provide a paradigm for the stem cell mode of division, with the ability to both self-renew and produce daughters that differentiate. The transcription factor RNT-1 and its DNA binding partner BRO-1 (homologues of the mammalian cancer-associated stem cell regulators RUNX and CBFβ, respectively) are known rate-limiting regulators of seam cell proliferation. Here, we show, using a combination of comparative genomics and DNA binding assays, that bro-1 expression ...[more]