Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
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ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC3150510 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
Liu Xiangdong X Invernizzi Pietro P Lu Yue Y Kosoy Roman R Lu Yan Y Bianchi Ilaria I Podda Mauro M Xu Chun C Xie Gang G Macciardi Fabio F Selmi Carlo C Lupoli Sara S Shigeta Russell R Ransom Michael M Lleo Ana A Lee Annette T AT Mason Andrew L AL Myers Robert P RP Peltekian Kevork M KM Ghent Cameron N CN Bernuzzi Francesca F Zuin Massimo M Rosina Floriano F Borghesio Elisabetta E Floreani Annarosa A Lazzari Roberta R Niro Grazia G Andriulli Angelo A Muratori Luigi L Muratori Paolo P Almasio Piero L PL Andreone Pietro P Margotti Marzia M Brunetto Maurizia M Coco Barbara B Alvaro Domenico D Bragazzi Maria C MC Marra Fabio F Pisano Alessandro A Rigamonti Cristina C Colombo Massimo M Marzioni Marco M Benedetti Antonio A Fabris Luca L Strazzabosco Mario M Portincasa Piero P Palmieri Vincenzo O VO Tiribelli Claudio C Croce Lory L Bruno Savino S Rossi Sonia S Vinci Maria M Prisco Cleofe C Mattalia Alberto A Toniutto Pierluigi P Picciotto Antonio A Galli Andrea A Ferrari Carlo C Ferrari Carlo C Colombo Silvia S Casella Giovanni G Morini Lorenzo L Caporaso Nicola N Colli Agostino A Spinzi Giancarlo G Montanari Renzo R Gregersen Peter K PK Heathcote E Jenny EJ Hirschfield Gideon M GM Siminovitch Katherine A KA Amos Christopher I CI Gershwin M Eric ME Seldin Michael F MF
Nature genetics 20100718 8
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38). ...[more]
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