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Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

ABSTRACT: Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV(1)/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV(1) (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

SUBMITTER: Hancock DB

PROVIDER: S-EPMC2832852 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

Hancock Dana B DB Eijgelsheim Mark M Wilk Jemma B JB Gharib Sina A SA Loehr Laura R LR Marciante Kristin D KD Franceschini Nora N van Durme Yannick M T A YM Chen Ting-Hsu TH Barr R Graham RG Schabath Matthew B MB Couper David J DJ Brusselle Guy G GG Psaty Bruce M BM van Duijn Cornelia M CM Rotter Jerome I JI Uitterlinden André G AG Hofman Albert A Punjabi Naresh M NM Rivadeneira Fernando F Morrison Alanna C AC Enright Paul L PL North Kari E KE Heckbert Susan R SR Lumley Thomas T Stricker Bruno H C BH O'Connor George T GT London Stephanie J SJ

Nature genetics 20091213 1

Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk ...[more]

PMID: 20010835

Dataset Information

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

Publications

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

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