Ontology highlight
ABSTRACT:
SUBMITTER: Kussius CL
PROVIDER: S-EPMC3150747 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Kussius Cassandra L CL Kaur Navjot N Popescu Gabriela K GK
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090501 21
Neurosteroids are potent neuromodulators which act in part by binding to and modifying the activity of neurotransmitter-gated channels. Pregnanolone sulfate (PAS) is an endogenous neurosteroid that inhibits NMDA receptors and is neuroprotective in vivo. To delineate the mechanism of NMDA receptor inhibition by pregnanolone sulfate we used kinetic analyses of equilibrium single-channel currents recorded from individual GluN1/GluN2A receptors. Results show that PAS (0.1 mM) reduces single-channel ...[more]