MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
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ABSTRACT:
SUBMITTER: Bernard LP
PROVIDER: S-EPMC4416788 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
Bernard Laura P LP Zhang Huaye H
PloS one 20150501 5
The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs), are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocamp ...[more]
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