Ontology highlight
ABSTRACT:
SUBMITTER: Simon GM
PROVIDER: S-EPMC3150830 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Simon Gabriel M GM Dix Melissa M MM Cravatt Benjamin F BF
ACS chemical biology 20090601 6
Two proteomic methods were recently introduced to globally map proteolytic cleavage events in biological systems, one that characterized proteolyzed proteins by differential gel migration (PROTOMAP) and the other by enzymatic tagging and enrichment of the nascent N-terminal peptides generated by proteolysis (Subtiligase). Both technologies were applied to apoptosis, and each uncovered hundreds of novel proteolytic events. An initial survey, however, revealed only minimal overlap in the two data ...[more]