Nanoscale studies of protein-membrane interactions in blood clotting.
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ABSTRACT:
SUBMITTER: Morrissey JH
PROVIDER: S-EPMC3151027 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Nanoscale studies of protein-membrane interactions in blood clotting.
Morrissey J H JH Tajkhorshid E E Rienstra C M CM
Journal of thrombosis and haemostasis : JTH 20110701
Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on ...[more]
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