Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh S
PROVIDER: S-EPMC5529531 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Ghosh Snehasish S Mukherjee Sanchita S Dutta Chiranjit C Chakraborty Kasturee K Gayen Paramita P Jan Somnath S Bhattacharyya Dhananjay D Roy Rituparna Sinha RS
Scientific reports 20170726 1
Designing biologically inspired nanoscale molecular assembly with desired functionality is a challenging endeavour. Here we report the designing of fibrin-inspired nanostructured peptide based sealants which facilitate remarkably fast entrapping of blood corpuscles (~28 seconds) in contrast to fibrin (~56 seconds). Our engineered sealants are stabilized by lysine-aspartate ionic interactions and also by N<sup>ε</sup>(γ-glutamyl) lysine isopeptide bond mediated covalent interaction. Each sealant ...[more]