Ontology highlight
ABSTRACT:
SUBMITTER: Benini S
PROVIDER: S-EPMC3151116 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Benini Stefano S Wilson Keith K
Acta crystallographica. Section F, Structural biology and crystallization communications 20110726 Pt 8
The 1.5 Å resolution crystal structure of the Mycobacterium tuberculosis soluble inorganic pyrophosphatase Rv3628 at pH 7.0 is reported. The M. tuberculosis and M. leprae genomes include genes for the only two family I inorganic pyrophosphatases known to contain two histidines in the active site. The role of these two residues in catalysis is not fully understood. Mutational and functional studies of the M. tuberculosis enzyme showed that His21 and His86 are not essential for pyrophosphate hydro ...[more]