Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.
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ABSTRACT:
SUBMITTER: Forseth RR
PROVIDER: S-EPMC3151163 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.
Forseth Ry R RR Fox Ellen M EM Chung DaWoon D Howlett Barbara J BJ Keller Nancy P NP Schroeder Frank C FC
Journal of the American Chemical Society 20110606 25
Gliotoxin, a major product of the gli non-ribosomal peptide synthetase gene cluster, is strongly associated with virulence of the opportunistic human pathogen Aspergillus fumigatus. Despite identification of the gli cluster, the pathway of gliotoxin biosynthesis has remained elusive, in part because few potential intermediates have been identified. In addition, previous studies suggest that knowledge of gli-dependent metabolites is incomplete. Here we use differential analysis by 2D NMR spectros ...[more]
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