Ontology highlight
ABSTRACT:
SUBMITTER: Crone WJ
PROVIDER: S-EPMC5103208 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Crone William J K WJ Vior Natalia M NM Santos-Aberturas Javier J Schmitz Lukas G LG Leeper Finian J FJ Truman Andrew W AW
Angewandte Chemie (International ed. in English) 20160704 33
Bottromycin A2 is a structurally unique ribosomally synthesized and post-translationally modified peptide (RiPP) that possesses potent antibacterial activity towards multidrug-resistant bacteria. The structural novelty of bottromycin stems from its unprecedented macrocyclic amidine and rare β-methylated amino acid residues. The N-terminus of a precursor peptide (BtmD) is converted into bottromycin A2 by tailoring enzymes encoded in the btm gene cluster. However, little was known about key transf ...[more]