Ontology highlight
ABSTRACT:
SUBMITTER: Lamb CA
PROVIDER: S-EPMC3152195 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Lamb Christopher A CA McCann Rebecca K RK Stöckli Jacqueline J James David E DE Bryant Nia J NJ
Traffic (Copenhagen, Denmark) 20100920 11
A major consequence of insulin binding its receptor on fat and muscle cells is translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the cell surface where it serves to clear glucose from the bloodstream. Sorting of GLUT4 into its insulin-sensitive store requires the GGA [Golgi-localized, γ-ear-containing, ADP ribosylation factor (ARF)-binding] adaptor proteins, but the signal on GLUT4 to direct this sorting step is unknown. Here, we have identified a role fo ...[more]