Ontology highlight
ABSTRACT:
SUBMITTER: Elam CA
PROVIDER: S-EPMC3152255 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Cytoskeleton (Hoboken, N.J.) 20110701 7
Analysis of Chlamydomonas axonemes revealed that the protein phosphatase, PP2A, is localized to the outer doublet microtubules and is implicated in regulation of dynein-driven motility. We tested the hypothesis that PP2A is localized to the axoneme by a specialized, highly conserved 55-kDa B-type subunit identified in the Chlamydomonas flagellar proteome. The B-subunit gene is defective in the motility mutant pf4. Consistent with our hypothesis, both the B- and C- subunits of PP2A fail to assemb ...[more]