Ontology highlight
ABSTRACT:
SUBMITTER: Laulier C
PROVIDER: S-EPMC3152340 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Laulier Corentin C Cheng Anita A Stark Jeremy M JM
Nucleic acids research 20110331 14
Homology-directed repair (HDR) is essential to limit mutagenesis, chromosomal instability (CIN) and tumorigenesis. We have characterized the consequences of HDR deficiency on anaphase, using markers for incomplete chromosome separation: DAPI-bridges and Ultra-fine bridges (UFBs). We show that multiple HDR factors (Rad51, Brca2 and Brca1) are critical for complete chromosome separation during anaphase, while another chromosome break repair pathway, non-homologous end joining, does not affect chro ...[more]