Ontology highlight
ABSTRACT:
SUBMITTER: Davis L
PROVIDER: S-EPMC3956201 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Davis Luther L Maizels Nancy N
Proceedings of the National Academy of Sciences of the United States of America 20140220 10
DNA nicks are the most common form of DNA damage, and if unrepaired can give rise to genomic instability. In human cells, nicks are efficiently repaired via the single-strand break repair pathway, but relatively little is known about the fate of nicks not processed by that pathway. Here we show that homology-directed repair (HDR) at nicks occurs via a mechanism distinct from HDR at double-strand breaks (DSBs). HDR at nicks, but not DSBs, is associated with transcription and is eightfold more eff ...[more]