Ontology highlight
ABSTRACT:
SUBMITTER: Le Bihan YV
PROVIDER: S-EPMC3152353 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Le Bihan Yann-Vaï YV Angeles Izquierdo Maria M Coste Franck F Aller Pierre P Culard Françoise F Gehrke Tim H TH Essalhi Kadija K Carell Thomas T Castaing Bertrand B
Nucleic acids research 20110412 14
DNA base-damage recognition in the base excision repair (BER) is a process operating on a wide variety of alkylated, oxidized and degraded bases. DNA glycosylases are the key enzymes which initiate the BER pathway by recognizing and excising the base damages guiding the damaged DNA through repair synthesis. We report here biochemical and structural evidence for the irreversible entrapment of DNA glycosylases by 5-hydroxy-5-methylhydantoin, an oxidized thymine lesion. The first crystal structure ...[more]