Ontology highlight
ABSTRACT:
SUBMITTER: Sorimachi H
PROVIDER: S-EPMC3153876 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Sorimachi Hiroyuki H Hata Shoji S Ono Yasuko Y
Proceedings of the Japan Academy. Series B, Physical and biological sciences 20110101 6
Calpain is an intracellular Ca2+-dependent cysteine protease (EC 3.4.22.17; Clan CA, family C02) discovered in 1964. It was also called CANP (Ca2+-activated neutral protease) as well as CASF, CDP, KAF, etc. until 1990. Calpains are found in almost all eukaryotes and a few bacteria, but not in archaebacteria. Calpains have a limited proteolytic activity, and function to transform or modulate their substrates' structures and activities; they are therefore called, "modulator proteases." In the huma ...[more]