A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo.
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ABSTRACT:
SUBMITTER: Cronican JJ
PROVIDER: S-EPMC3154086 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo.
Cronican James J JJ Beier Kevin T KT Davis Tina N TN Tseng Jen-Chieh JC Li Weida W Thompson David B DB Shih Allen F AF May Erin M EM Cepko Constance L CL Kung Andrew L AL Zhou Qiao Q Liu David R DR
Chemistry & biology 20110701 7
We discovered a class of naturally occurring human proteins with unusually high net positive charge that can potently deliver proteins in functional form into mammalian cells both in vitro and also in murine retina, pancreas, and white adipose tissues in vivo. These findings represent diverse macromolecule delivery agents for in vivo applications, and also raise the possibility that some of these human proteins may penetrate cells as part of their native biological functions. ...[more]
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