Ontology highlight
ABSTRACT:
SUBMITTER: Zhuang J
PROVIDER: S-EPMC3154587 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Zhuang Jieqiu J Zhang Xuemei X Wang Dexuan D Li Juan J Zhou Bo B Shi Zhen Z Gu Dingying D Denson Donald D DD Eaton Douglas C DC Cai Hui H
American journal of physiology. Renal physiology 20110525 2
WNK [with no lysine (k)] kinase is a serine/threonine kinase subfamily. Mutations in two of the WNK kinases result in pseudohypoaldosteronism type II (PHA II) characterized by hypertension, hyperkalemia, and metabolic acidosis. Recent studies showed that both WNK1 and WNK4 inhibit ROMK activity. However, little is known about the effect of WNK kinases on Maxi K, a large-conductance Ca(2+) and voltage-activated potassium (K) channel. Here, we report that WNK4 wild-type (WT) significantly inhibits ...[more]