Ontology highlight
ABSTRACT:
SUBMITTER: Castaneda-Bueno M
PROVIDER: S-EPMC5293014 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Castañeda-Bueno Maria M Arroyo Juan Pablo JP Zhang Junhui J Puthumana Jeremy J Yarborough Orlando O Shibata Shigeru S Rojas-Vega Lorena L Gamba Gerardo G Rinehart Jesse J Lifton Richard P RP
Proceedings of the National Academy of Sciences of the United States of America 20170117 5
With-no-lysine kinase 4 (WNK4) regulates electrolyte homeostasis and blood pressure. WNK4 phosphorylates the kinases SPAK (Ste20-related proline alanine-rich kinase) and OSR1 (oxidative stress responsive kinase), which then phosphorylate and activate the renal Na-Cl cotransporter (NCC). WNK4 levels are regulated by binding to Kelch-like 3, targeting WNK4 for ubiquitylation and degradation. Phosphorylation of Kelch-like 3 by PKC or PKA downstream of AngII or vasopressin signaling, respectively, a ...[more]