Ontology highlight
ABSTRACT:
SUBMITTER: Phelps CJ
PROVIDER: S-EPMC3154759 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Phelps Carol J CJ Koike Chihiro C Vaught Todd D TD Boone Jeremy J Wells Kevin D KD Chen Shu-Hung SH Ball Suyapa S Specht Susan M SM Polejaeva Irina A IA Monahan Jeff A JA Jobst Pete M PM Sharma Sugandha B SB Lamborn Ashley E AE Garst Amy S AS Moore Marilyn M Demetris Anthony J AJ Rudert William A WA Bottino Rita R Bertera Suzanne S Trucco Massimo M Starzl Thomas E TE Dai Yifan Y Ayares David L DL
Science (New York, N.Y.) 20021219 5605
The enzyme alpha1,3-galactosyltransferase (alpha1,3GT or GGTA1) synthesizes alpha1,3-galactose (alpha1,3Gal) epitopes (Galalpha1,3Galbeta1,4GlcNAc-R), which are the major xenoantigens causing hyperacute rejection in pig-to-human xenotransplantation. Complete removal of alpha1,3Gal from pig organs is the critical step toward the success of xenotransplantation. We reported earlier the targeted disruption of one allele of the alpha1,3GT gene in cloned pigs. A selection procedure based on a bacteria ...[more]