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Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.

ABSTRACT: Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair. However, whether condensin I physically associates with DNA damage sites and how PARP1 may contribute to this process were unclear. We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.

SUBMITTER: Kong X 

PROVIDER: S-EPMC3155556 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.

Kong Xiangduo X   Stephens Jared J   Ball Alexander R AR   Heale Jason T JT   Newkirk Daniel A DA   Berns Michael W MW   Yokomori Kyoko K  

PloS one 20110812 8

Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair. However, whether condensin I physically associates with DNA damage sites and how PARP1 may contribute to this process were unclear. We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by PARP1 through its int  ...[more]

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